1. Explain the process of breathing (ventilation) in humans including the roles of the diaphragm, intercostal muscles, and pleural membranes. How does the body regulate this process?
2. Why does myoglobin have a higher oxygen-binding affinity than haemoglobin? Discuss its physiological importance?
| Characteristic | Hemoglobin | Myoglobin |
|---|---|---|
| Structure | 4 polypeptide chains (2α + 2β), 4 heme groups | 1 polypeptide chain, 1 heme group |
| Oxygen Binding | Cooperative (S-shaped curve) | Non-cooperative (hyperbolic curve) |
| Affinity for O₂ | Lower (P₅₀ ≈ 26 mmHg) | Higher (P₅₀ ≈ 2-3 mmHg) |
| Location | Red blood cells (circulation) | Muscle cells (storage) |
| Function | O₂ transport from lungs to tissues | O₂ storage in muscles for immediate use |
3. What is COPD and how it can be treated? Analyze the impact of genetic and environmental factors on the development of COPD.