Prepare with MCQs on the formulation and manufacturing of solid, semi-solid, liquid, and parenteral dosage forms. Explore key concepts, techniques, and quality standards to excel in your exams.
Solid Dosage Forms
- Which method is commonly used for manufacturing tablets?
- A) Sublimation
- B) Direct compression
- C) Freeze drying
- D) Distillation
- Answer: B
- Which of the following is a key excipient used as a binder in tablet formulations?
- A) Talc
- B) Magnesium stearate
- C) Polyvinylpyrrolidone (PVP)
- D) Sodium chloride
- Answer: C
- Direct compression is suitable for substances that possess:
- A) Poor solubility
- B) Excellent flow and compressibility
- C) High moisture content
- D) Low melting points
- Answer: B
- Which equipment is typically used for dry granulation?
- A) Rotary dryer
- B) Hammer mill
- C) Roller compactor
- D) V-Type mixer
- Answer: C
- The primary purpose of disintegrants in tablet formulation is to:
- A) Enhance the taste
- B) Facilitate tablet dissolution
- C) Provide color
- D) Increase stability
- Answer: B
- Which method is used when wet granulation is not feasible for tablet preparation?
- A) Freeze drying
- B) Direct compression
- C) Dry granulation
- D) Coating
- Answer: C
Semi-Solid Dosage Forms
- Ointments are classified as:
- A) Solid dosage forms
- B) Liquid dosage forms
- C) Semi-solid dosage forms
- D) Gaseous dosage forms
- Answer: C
- The fusion method for ointment preparation involves:
- A) Mixing solid ingredients only
- B) Grinding ingredients together
- C) Melting ingredients together
- D) Compressing powders into a solid form
- Answer: C
- What type of emulsion is typically used in water-in-oil creams?
- A) Oil-in-water
- B) Water-in-oil
- C) Oil suspension
- D) Gel-based
- Answer: B
- Which method is commonly used for incorporating finely divided solids into ointments?
- A) Fusion method
- B) Trituration method
- C) Blending
- D) Distillation
- Answer: B
- Gels are characterized by:
- A) Being entirely solid
- B) High water content and viscosity
- C) Low stability
- D) Being purely hydrophobic
- Answer: B
Liquid Dosage Forms
- The primary advantage of liquid dosage forms is:
- A) Ease of administration
- B) Longer shelf life
- C) Low cost
- D) Minimal side effects
- Answer: A
- Syrups typically contain:
- A) High amounts of alcohol
- B) Aqueous solutions with sugar
- C) Glycerin as the main ingredient
- D) No preservatives
- Answer: B
- For thermo-labile ingredients in syrups, the solution is:
- A) Heated continuously
- B) Mixed with ethanol
- C) Cooled before adding the ingredient
- D) Not used in the formulation
- Answer: C
- Which equipment is commonly used for large-scale liquid mixing?
- A) V-Type mixer
- B) Silverson homogenizer
- C) Hammer mill
- D) Ball mill
- Answer: B
- Oral solutions should be:
- A) Cloudy
- B) Homogeneous
- C) Partially dissolved
- D) Semi-solid
- Answer: B
Parenteral Dosage Forms
- Parenteral dosage forms are characterized by being:
- A) Solid formulations
- B) Administered via injection
- C) Taken orally
- D) For external use only
- Answer: B
- Sterilization is a critical step in manufacturing:
- A) Tablets
- B) Capsules
- C) Parenteral dosage forms
- D) Gels
- Answer: C
- Which sterilization method is used for heat-sensitive materials?
- A) Autoclaving
- B) Dry heat sterilization
- C) Filtration
- D) Radiation
- Answer: C
- Good Manufacturing Practice (GMP) requirements for injectables include:
- A) Low cost of production
- B) Non-sterile environment
- C) Pyrogen-free and sterile products
- D) Minimal quality checks
- Answer: C
- In parenteral formulations, the primary purpose of a buffer is to:
- A) Increase viscosity
- B) Stabilize pH
- C) Act as a preservative
- D) Provide flavor
- Answer: B
- Intravenous preparations should be:
- A) Hypertonic only
- B) Free from particulates
- C) Administered slowly
- D) Opaque
- Answer: B
General Formulation and Manufacturing Principles
- Which excipient is used to improve the solubility of poorly soluble drugs?
- A) Lubricants
- B) Solubilizers
- C) Sweeteners
- D) Disintegrants
- Answer: B
- The purpose of antioxidants in formulations is to:
- A) Enhance color
- B) Prevent oxidation
- C) Act as diluents
- D) Increase viscosity
- Answer: B
- A common suspending agent used in suspensions is:
- A) Talc
- B) Acacia
- C) Ethanol
- D) Sodium chloride
- Answer: B
- Buffers are used in liquid dosage forms to:
- A) Adjust the color
- B) Maintain the desired pH
- C) Increase solubility
- D) Provide isotonicity
- Answer: B
- The addition of a preservative to a dosage form helps to:
- A) Reduce viscosity
- B) Increase flavor
- C) Prevent microbial growth
- D) Enhance stability
- Answer: C
- Gelatin is commonly used as a shell material in:
- A) Tablets
- B) Capsules
- C) Ointments
- D) Solutions
- Answer: B
- The primary purpose of coating tablets is to:
- A) Increase size
- B) Improve appearance and stability
- C) Reduce cost
- D) Enhance dissolution
- Answer: B
- An ideal pharmaceutical excipient should:
- A) Be reactive
- B) Enhance drug stability
- C) Cause side effects
- D) Be expensive
- Answer: B
