Unit 6: Gastrointestinal Drugs MCQs

Master Unit 6 with MCQs on gastrointestinal drugs. Cover key topics like antacids, antiemetics, laxatives, and proton pump inhibitors to boost your exam readiness.

  1. What is the primary therapeutic use of proton pump inhibitors (PPIs) like omeprazole?
  • A) Constipation relief
  • B) Diarrhea treatment
  • C) Peptic ulcer disease
  • D) Antiemetic action
  • Answer: C
  1. Which drug acts by creating a protective barrier over ulcers?
  • A) Misoprostol
  • B) Sucralfate
  • C) Omeprazole
  • D) Loperamide
  • Answer: B
  1. Metronidazole is primarily used to treat infections caused by which microorganism?
  • A) Fungi
  • B) Bacteria
  • C) H. pylori
  • D) Viruses
  • Answer: C
  1. Which adverse effect is common with prolonged use of aluminum hydroxide antacids?
  • A) Diarrhea
  • B) Constipation
  • C) Headache
  • D) Drowsiness
  • Answer: B
  1. What is the main action of antiemetics like metoclopramide?
  • A) Inhibits H2 receptors
  • B) Blocks D2 receptors
  • C) Stimulates gastric acid secretion
  • D) Inhibits prostaglandins
  • Answer: B
  1. Which class of drugs does cimetidine belong to?
  • A) Proton pump inhibitors
  • B) Antacids
  • C) H2 receptor antagonists
  • D) Laxatives
  • Answer: C
  1. What is the mechanism of action of misoprostol in treating gastric ulcers?
  • A) Reduces gastric acid secretion
  • B) Neutralizes stomach acidity
  • C) Promotes mucus and bicarbonate secretion
  • D) Increases peristalsis
  • Answer: A
  1. Loperamide is used to treat which condition?
  • A) Nausea
  • B) Diarrhea
  • C) Constipation
  • D) Peptic ulcer
  • Answer: B
  1. Which drug is used as a stool softener?
  • A) Sucralfate
  • B) Docusate
  • C) Metoclopramide
  • D) Misoprostol
  • Answer: B
  1. Proton pump inhibitors work by inhibiting which enzyme?
    • A) Gastric lipase
    • B) Pepsinogen
    • C) H+/K+ ATPase
    • D) Amylase
    • Answer: C
  2. Which medication is used to treat motion sickness?
    • A) Metronidazole
    • B) Scopolamine
    • C) Omeprazole
    • D) Sucralfate
    • Answer: B
  3. What adverse effect is associated with misoprostol?
    • A) Constipation
    • B) Uterine contractions
    • C) Hypertension
    • D) Bradycardia
    • Answer: B
  4. Aluminum hydroxide, as an antacid, primarily acts by:
    • A) Blocking H2 receptors
    • B) Neutralizing gastric acidity
    • C) Inhibiting gastric proton pump
    • D) Enhancing gastric motility
    • Answer: B
  5. Which agent is commonly used in H. pylori eradication therapy?
    • A) Sucralfate
    • B) Omeprazole
    • C) Metronidazole
    • D) Misoprostol
    • Answer: C
  6. Castor oil acts as a:
    • A) Osmotic laxative
    • B) Stimulant laxative
    • C) Stool softener
    • D) Antiemetic
    • Answer: B
  7. What is a contraindication for the use of loperamide?
    • A) Chronic constipation
    • B) Infectious diarrhea
    • C) Hypertension
    • D) Peptic ulcer disease
    • Answer: B
  8. Which condition can be treated with H2 receptor antagonists?
    • A) Asthma
    • B) Diabetes
    • C) Gastroesophageal reflux disease (GERD)
    • D) Hypertension
    • Answer: C
  9. Dimenhydrinate is classified as a/an:
    • A) H2 receptor antagonist
    • B) Antiemetic
    • C) Laxative
    • D) Proton pump inhibitor
    • Answer: B
  10. The therapeutic effect of lactulose involves:
    • A) Increasing bile production
    • B) Acting as an osmotic laxative
    • C) Neutralizing stomach acid
    • D) Reducing bile flow
    • Answer: B
  11. Which drug is commonly used for peptic ulcer prevention in patients taking NSAIDs?
    • A) Metronidazole
    • B) Sucralfate
    • C) Misoprostol
    • D) Loperamide
    • Answer: C
  12. Antacids should not be taken with which class of drugs due to absorption interference?
    • A) Antibiotics
    • B) Antihistamines
    • C) Diuretics
    • D) Analgesics
    • Answer: A
  13. What is the mechanism of action of H2 antagonists like cimetidine?
    • A) Inhibit proton pumps
    • B) Block histamine at H2 receptors
    • C) Stimulate mucus secretion
    • D) Neutralize gastric acid
    • Answer: B
  14. Scopolamine is most effective in treating:
    • A) Peptic ulcers
    • B) Motion sickness
    • C) Constipation
    • D) GERD
    • Answer: B
  15. A common side effect of proton pump inhibitors is:
    • A) Hypertension
    • B) Constipation
    • C) Increased gastric bacteria
    • D) Tachycardia
    • Answer: C
  16. Which class of drugs is used to enhance mucosal protection in peptic ulcer disease?
    • A) Proton pump inhibitors
    • B) H2 antagonists
    • C) Mucosal protective agents
    • D) Antacids
    • Answer: C
  17. Docusate acts by:
    • A) Neutralizing stomach acid
    • B) Stimulating peristalsis
    • C) Softening stool by emulsifying fecal matter
    • D) Blocking D2 receptors
    • Answer: C
  18. Which drug is used to accelerate gastric emptying?
    • A) Metoclopramide
    • B) Sucralfate
    • C) Misoprostol
    • D) Loperamide
    • Answer: A
  19. Omeprazole is used primarily to treat:
    • A) Constipation
    • B) GERD
    • C) Asthma
    • D) Hypertension
    • Answer: B
  20. Which of the following is an osmotic laxative?
    • A) Sucralfate
    • B) Lactulose
    • C) Metoclopramide
    • D) Scopolamine
    • Answer: B
  21. Dimenhydrinate is most commonly used to manage:
    • A) GERD
    • B) Constipation
    • C) Motion sickness
    • D) Peptic ulcers
    • Answer: C
  22. Aluminum hydroxide may cause which gastrointestinal side effect?
    • A) Diarrhea
    • B) Constipation
    • C) Nausea
    • D) Vomiting
    • Answer: B
  23. The primary action of sucralfate in treating ulcers is to:
    • A) Neutralize stomach acid
    • B) Create a protective barrier
    • C) Reduce gastric motility
    • D) Stimulate bile secretion
    • Answer: B
  24. Which drug can prevent NSAID-induced ulcers by increasing mucus production?
    • A) Sucralfate
    • B) Omeprazole
    • C) Misoprostol
    • D) Cimetidine
    • Answer: C
  25. Prolonged use of proton pump inhibitors may increase the risk of:
    • A) Bacterial overgrowth
    • B) Hypertension
    • C) Constipation
    • D) Acid reflux
    • Answer: A
  26. Which drug class does metoclopramide belong to?
    • A) Antacids
    • B) Antiarrhythm

ics
– C) Prokinetic agents
– D) Laxatives
Answer: C

  1. Scopolamine prevents motion sickness by blocking:
    • A) H2 receptors
    • B) Acetylcholine at muscarinic receptors
    • C) Dopamine receptors
    • D) Gastric proton pumps
    • Answer: B
  2. A laxative that works by increasing water content in stools is:
    • A) Sucralfate
    • B) Misoprostol
    • C) Lactulose
    • D) Metoclopramide
    • Answer: C
  3. Which medication is used to reduce nausea in chemotherapy patients?
    • A) Scopolamine
    • B) Metoclopramide
    • C) Loperamide
    • D) Sucralfate
    • Answer: B
  4. Proton pump inhibitors are indicated for the treatment of:
    • A) Asthma
    • B) GERD and ulcers
    • C) Hypertension
    • D) Constipation
    • Answer: B
  5. Which gastrointestinal drug can increase uterine contractions?
    • A) Omeprazole
    • B) Sucralfate
    • C) Misoprostol
    • D) Loperamide
    • Answer: C
  6. Docusate is best used as a:
    • A) Stool softener
    • B) Proton pump inhibitor
    • C) Antiemetic
    • D) Antidiarrheal
    • Answer: A
  7. Aluminum hydroxide’s primary mechanism is:
    • A) Gastric emptying enhancement
    • B) Neutralizing stomach acid
    • C) Promoting peristalsis
    • D) Stimulating bile secretion
    • Answer: B
  8. Which adverse effect is associated with scopolamine?
    • A) Diarrhea
    • B) Dry mouth
    • C) Increased appetite
    • D) Hypotension
    • Answer: B
  9. Lactulose helps in constipation by:
    • A) Blocking sodium channels
    • B) Reducing bile secretion
    • C) Increasing osmotic pressure in the colon
    • D) Neutralizing stomach acid
    • Answer: C
  10. Which drug works by inhibiting H+/K+ ATPase?
    • A) Misoprostol
    • B) Omeprazole
    • C) Sucralfate
    • D) Metoclopramide
    • Answer: B
  11. Scopolamine is used primarily for:
    • A) Diarrhea
    • B) Motion sickness
    • C) Heartburn
    • D) Constipation
    • Answer: B
  12. Proton pump inhibitors should be taken:
    • A) After meals
    • B) Before meals
    • C) At bedtime
    • D) Only with antacids
    • Answer: B
  13. Which condition is commonly treated with misoprostol?
    • A) GERD
    • B) Constipation
    • C) NSAID-induced ulcers
    • D) Motion sickness
    • Answer: C
  14. Dimenhydrinate is an example of a/an:
    • A) H2 receptor blocker
    • B) Laxative
    • C) Antiemetic
    • D) Antacid
    • Answer: C
  15. The primary action of loperamide in the gastrointestinal tract is:
    • A) Stimulating peristalsis
    • B) Inhibiting gastric secretion
    • C) Reducing bowel motility
    • D) Neutralizing stomach acid
    • Answer: C

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