MCQs on Added Substances: Preservatives, Antioxidants, Solubilizers & More

Prepare with MCQs on added substances like preservatives, antioxidants, solubilizers, suspending agents, buffers, and stabilizers. Understand their roles in pharmaceutics and strengthen your exam readiness.

Preservatives

  1. What is the primary function of preservatives in pharmaceuticals?
  • A) Enhance flavor
  • B) Prevent microbial growth
  • C) Increase viscosity
  • D) Improve color stability
  • Answer: B
  1. Which of the following is a commonly used preservative in oral formulations?
  • A) Ascorbic acid
  • B) Sodium benzoate
  • C) Glycerin
  • D) Mineral oil
  • Answer: B
  1. Methylparaben is commonly used as a preservative in:
  • A) Injections
  • B) Creams and ointments
  • C) Gels
  • D) Powders
  • Answer: B
  1. Benzoic acid is most effective as a preservative at:
  • A) pH below 4.5
  • B) pH 7.0
  • C) pH above 8.0
  • D) Neutral pH
  • Answer: A
  1. Chlorobutanol is used as a preservative in:
  • A) Oral solutions
  • B) Ophthalmic solutions
  • C) Tablets
  • D) Capsules
  • Answer: B

Antioxidants

  1. The primary purpose of antioxidants in pharmaceutical products is to:
  • A) Increase viscosity
  • B) Prevent oxidation
  • C) Act as sweeteners
  • D) Provide color
  • Answer: B
  1. Which antioxidant is commonly used in aqueous formulations?
  • A) Butylated hydroxyanisole (BHA)
  • B) Ascorbic acid
  • C) Glycerin
  • D) Talc
  • Answer: B
  1. Sodium bisulfite is used in parenteral preparations as:
  • A) A preservative
  • B) A sweetener
  • C) An antioxidant
  • D) A solubilizer
  • Answer: C
  1. What is the primary role of chelating agents like EDTA in formulations?
  • A) Enhance solubility
  • B) Inhibit microbial growth
  • C) Stabilize antioxidants
  • D) Improve taste
  • Answer: C
  1. Which antioxidant is suitable for use in oil-based formulations?
    • A) Ascorbic acid
    • B) Butylated hydroxytoluene (BHT)
    • C) Sodium benzoate
    • D) Citric acid
    • Answer: B

Solubilizers

  1. Solubilizers are primarily used to:
    • A) Increase the stability of a solution
    • B) Improve the solubility of hydrophobic drugs
    • C) Enhance taste
    • D) Act as thickeners
    • Answer: B
  2. Which of the following is commonly used as a solubilizer in oral solutions?
    • A) Ethanol
    • B) Starch
    • C) Talc
    • D) Bentonite
    • Answer: A
  3. Glycerin is used as a solubilizer because of its:
    • A) Sweet taste
    • B) Low viscosity
    • C) High solubility in water
    • D) Antimicrobial properties
    • Answer: C
  4. Which solubilizer is suitable for parenteral formulations?
    • A) Ethanol
    • B) Corn oil
    • C) Mineral oil
    • D) Propylene glycol
    • Answer: D
  5. Polyethylene glycol (PEG) is often used as a:
    • A) Sweetener
    • B) Solubilizer
    • C) Buffer
    • D) Preservative
    • Answer: B

Suspending Agents

  1. Suspending agents are added to:
    • A) Increase solubility
    • B) Stabilize suspensions by increasing viscosity
    • C) Act as preservatives
    • D) Reduce particle size
    • Answer: B
  2. Which of the following is commonly used as a suspending agent?
    • A) Sodium chloride
    • B) Xanthan gum
    • C) Ascorbic acid
    • D) Ethanol
    • Answer: B
  3. Tragacanth is used in suspensions as a:
    • A) Buffer
    • B) Preservative
    • C) Suspending agent
    • D) Solubilizer
    • Answer: C
  4. Carboxymethylcellulose (CMC) is classified as a:
    • A) Sweetener
    • B) Solubilizer
    • C) Suspending agent
    • D) Antioxidant
    • Answer: C
  5. What is the main function of a suspending agent in a suspension?
    • A) Prevent sedimentation
    • B) Enhance taste
    • C) Stabilize pH
    • D) Provide color
    • Answer: A

Buffers

  1. Buffers are added to formulations to:
    • A) Enhance flavor
    • B) Maintain a stable pH
    • C) Increase viscosity
    • D) Act as solubilizers
    • Answer: B
  2. Which of the following is a common buffering agent?
    • A) Glycerin
    • B) Sodium acetate
    • C) Talc
    • D) Bentonite
    • Answer: B
  3. Buffers are especially important in which type of formulation?
    • A) Tablets
    • B) Ointments
    • C) Ophthalmic solutions
    • D) Capsules
    • Answer: C
  4. Citric acid-sodium citrate is commonly used as a buffer in:
    • A) Parenteral formulations
    • B) Gels
    • C) Capsules
    • D) Powders
    • Answer: A
  5. Buffers help maintain stability by:
    • A) Preventing microbial growth
    • B) Stabilizing pH levels
    • C) Enhancing solubility
    • D) Reducing viscosity
    • Answer: B

Stabilizers

  1. Stabilizers are used to:
    • A) Enhance flavor
    • B) Prevent degradation of active ingredients
    • C) Act as sweeteners
    • D) Increase solubility
    • Answer: B
  2. Which of the following acts as a stabilizer in emulsions?
    • A) Sodium chloride
    • B) Tween 80
    • C) Ascorbic acid
    • D) Xanthan gum
    • Answer: B
  3. Antioxidants can also function as:
    • A) Preservatives
    • B) Stabilizers
    • C) Solubilizers
    • D) Sweeteners
    • Answer: B
  4. Chelating agents like EDTA help to:
    • A) Enhance solubility
    • B) Stabilize metal ions
    • C) Increase viscosity
    • D) Provide flavor
    • Answer: B
  5. Which is a commonly used stabilizer in parenteral formulations?
    • A) Xanthan gum
    • B) Propylene glycol
    • C) Sodium bisulfite
    • D) Talc
    • Answer: C

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