Prepare for Pharmacology II with MCQs on the Central Nervous System (CNS). Cover key topics like neurotransmitters, CNS drugs, mechanisms of action, and therapeutic uses to ace your exams.
- What is the primary neurotransmitter deficiency in Parkinson’s disease?
- A) Acetylcholine
- B) Dopamine
- C) Serotonin
- D) GABA
- Answer: B
- Levodopa is commonly combined with carbidopa to:
- A) Increase its absorption
- B) Prevent peripheral conversion to dopamine
- C) Enhance the release of dopamine
- D) Reduce side effects on the heart
- Answer: B
- Which drug class is primarily used to treat generalized anxiety disorder?
- A) Barbiturates
- B) Benzodiazepines
- C) Antipsychotics
- D) Antiepileptics
- Answer: B
- Barbiturates enhance the activity of which neurotransmitter?
- A) Dopamine
- B) Acetylcholine
- C) Serotonin
- D) GABA
- Answer: D
- Which CNS stimulant inhibits the reuptake of monoamines?
- A) Nicotine
- B) Cocaine
- C) Caffeine
- D) LSD
- Answer: B
- Antipsychotic drugs primarily target which type of receptor?
- A) GABA receptors
- B) Dopamine receptors
- C) Serotonin receptors
- D) Cholinergic receptors
- Answer: B
- What is a common side effect of long-term levodopa therapy?
- A) Bradykinesia
- B) Dyskinesia
- C) Tachycardia
- D) Insomnia
- Answer: B
- Which drug is used for the chronic treatment of open-angle glaucoma?
- A) Physostigmine
- B) Atropine
- C) Echothiophate
- D) Succinylcholine
- Answer: C
- In the treatment of epilepsy, phenytoin acts by:
- A) Enhancing GABA activity
- B) Blocking sodium channels
- C) Inhibiting calcium channels
- D) Increasing serotonin release
- Answer: B
- SSRIs primarily function by:
- A) Blocking dopamine receptors
- B) Inhibiting serotonin reuptake
- C) Enhancing norepinephrine release
- D) Binding to GABA receptors
- Answer: B
- The mechanism of action of benzodiazepines involves:
- A) Inhibiting GABA uptake
- B) Modulating GABA receptors
- C) Blocking serotonin reuptake
- D) Increasing dopamine synthesis
- Answer: B
- Which antidepressant class blocks serotonin and norepinephrine reuptake?
- A) Tricyclic antidepressants
- B) Monoamine oxidase inhibitors
- C) Atypical antidepressants
- D) SSRIs
- Answer: A
- Gabapentin is an analog of which neurotransmitter?
- A) Dopamine
- B) GABA
- C) Acetylcholine
- D) Serotonin
- Answer: B
- Buspirone is an anxiolytic that lacks which property?
- A) Sedation
- B) Muscle relaxation
- C) Anticonvulsant effects
- D) All of the above
- Answer: D
- Which neurotransmitter is involved in the development of schizophrenia?
- A) Serotonin
- B) GABA
- C) Acetylcholine
- D) Dopamine
- Answer: D
- Clozapine is classified as a/an:
- A) Typical antipsychotic
- B) Atypical antipsychotic
- C) Antidepressant
- D) Anxiolytic
- Answer: B
- Which neurotransmitter’s activity is enhanced by monoamine oxidase inhibitors (MAOIs)?
- A) Dopamine
- B) Serotonin
- C) Norepinephrine
- D) All of the above
- Answer: D
- Tricyclic antidepressants can cause which anticholinergic side effect?
- A) Bradycardia
- B) Blurred vision
- C) Diarrhea
- D) Increased salivation
- Answer: B
- Phenelzine belongs to which class of drugs?
- A) MAO inhibitors
- B) SSRIs
- C) Tricyclic antidepressants
- D) Benzodiazepines
- Answer: A
- Which CNS stimulant increases blood pressure and heart rate?
- A) Cocaine
- B) Nicotine
- C) Caffeine
- D) Amphetamine
- Answer: B
- Which drug is used to reduce skeletal muscle spasms?
- A) Atropine
- B) Diazepam
- C) Fluoxetine
- D) Amitriptyline
- Answer: B
- Antiepileptic drugs aim to control seizures by:
- A) Increasing dopamine levels
- B) Enhancing inhibitory neurotransmission
- C) Blocking acetylcholine receptors
- D) Inhibiting serotonin reuptake
- Answer: B
- Which hallucinogen acts as a serotonin agonist?
- A) Cocaine
- B) Nicotine
- C) LSD
- D) Caffeine
- Answer: C
- Which condition is treated with atypical neuroleptics like clozapine?
- A) Depression
- B) Schizophrenia
- C) Generalized anxiety disorder
- D) Parkinson’s disease
- Answer: B
- Buspirone is most effective for which disorder?
- A) Panic disorder
- B) Major depressive disorder
- C) Generalized anxiety disorder
- D) Epilepsy
- Answer: C
- A common adverse effect of neuroleptics is:
- A) Tachycardia
- B) Extrapyramidal symptoms
- C) Hypotension
- D) Insomnia
- Answer: B
- Which drug is used to manage acute seizures?
- A) Diazepam
- B) Haloperidol
- C) Amitriptyline
- D) Clozapine
- Answer: A
- Phenytoin toxicity can cause:
- A) Bradycardia
- B) Gum hypertrophy
- C) Hyperthermia
- D) Increased blood pressure
- Answer: B
- Antipsychotic drugs can also have which antiemetic effect?
- A) Blocking dopamine receptors in the chemoreceptor trigger zone
- B) Enhancing acetylcholine release
- C) Inhibiting GABA uptake
- D) Blocking serotonin reuptake
- Answer: A
- Which of the following is a GABA receptor agonist used as an anxiolytic?
- A) Fluoxetine
- B) Diazepam
- C) Clozapine
- D) Haloperidol
- Answer: B
- Neuroleptic drugs block dopamine receptors primarily in which pathway?
- A) Nigrostriatal
- B) Mesolimbic
- C) Corticospinal
- D) Autonomic
- Answer: B
- What is a key adverse effect of barbiturates?
- A) Hyperactivity
- B) Respiratory depression
- C) Tachycardia
- D) Weight gain
- Answer: B
- Which antipsychotic is known for causing agranulocytosis?
- A) Chlorpromazine
- B) Haloperidol
- C) Clozapine
- D) Olanzapine
- Answer: C
- The therapeutic effect of SSRIs is typically observed after:
- A) 24 hours
- B) 1-2 weeks
- C) 4-6 weeks
- D) 8-10 weeks
- Answer: C
- Which antidepressant is often used for patients with insomnia?
- A) Fluoxetine
- B) Mirtazapine
- C) Duloxetine
- D) Amitripty
- – Answer: B
- What is the primary effect of CNS stimulants?
- A) Enhancing serotonin release
- B) Increasing neuronal firing rates
- C) Reducing dopamine reuptake
- D) Blocking GABA receptors
- Answer: B
- What is a therapeutic use of propranolol in CNS disorders?
- A) Anxiety reduction
- B) Epilepsy treatment
- C) Insomnia management
- D) Schizophrenia treatment
- Answer: A
- Which substance is considered both a stimulant and a drug of abuse?
- A) Amphetamine
- B) Phenobarbital
- C) Diazepam
- D) Levodopa
- Answer: A
- Fluoxetine is indicated for the treatment of:
- A) Epilepsy
- B) Depression
- C) Schizophrenia
- D) Parkinson’s disease
- Answer: B
- Which antiepileptic drug is also used for neuropathic pain?
- A) Phenytoin
- B) Gabapentin
- C) Diazepam
- D) Clozapine
- Answer: B
- MAOIs increase the risk of hypertensive crisis when combined with:
- A) Dairy products
- B) Foods rich in tyramine
- C) High-protein diets
- D) Salty foods
- Answer: B
- Which benzodiazepine has a long half-life, making it suitable for anxiety disorders?
- A) Midazolam
- B) Alprazolam
- C) Diazepam
- D) Lorazepam
- Answer: C
- Which antipsychotic has a higher risk of extrapyramidal side effects?
- A) Haloperidol
- B) Clozapine
- C) Olanzapine
- D) Risperidone
- Answer: A
- What is a common use for barbiturates in clinical practice?
- A) Anxiety management
- B) Seizure control
- C) Depression treatment
- D) Antipsychotic use
- Answer: B
- The drug used to reverse benzodiazepine overdose is:
- A) Naloxone
- B) Flumazenil
- C) Atropine
- D) Pralidoxime
- Answer: B
- Which medication is used to prevent seizures in patients undergoing alcohol withdrawal?
- A) Fluoxetine
- B) Diazepam
- C) Clozapine
- D) Buspirone
- Answer: B
- Nicotine acts on which type of receptor?
- A) GABA receptors
- B) Dopamine receptors
- C) Nicotinic acetylcholine receptors
- D) Serotonin receptors
- Answer: C
- Which condition is associated with reduced levels of serotonin and norepinephrine?
- A) Epilepsy
- B) Depression
- C) Schizophrenia
- D) Anxiety
- Answer: B
- Which drug is contraindicated in patients with narrow-angle glaucoma?
- A) Atropine
- B) Buspirone
- C) Clozapine
- D) Diazepam
- Answer: A
- Which neurotransmitter is primarily targeted by anxiolytic medications?
- A) Dopamine
- B) GABA
- C) Serotonin
- D) Acetylcholine
- Answer: B
